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For instance, NKCC2 has been found in insulin-secreting -cells (Zhu et al., 2011) or neurons of the hypothalamus (Konopacka et al., 2015), whereas NCC was detected in endothelial and smooth muscle cells, heart, lung and liver (Wang et al., 2015), adipocytes (Zhang et al., 2022a), and -cells as well (Zhang et al., 2022b)